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DELOS PUMPTM

Pulsatile or timed delivery is preferred for biopharmaceuticals such as parathyroid hormone and satiety hormones. The DELOS PUMPTM enables such patterned delivery. The system relies on the induction of electro-osmotic outflow of drug from a small implantable reservoir through the application of tiny electric current across specially designed DELOS PUMPTM membrane. Nanopor membranes fabricated with materials bearing charged surface groups (such as de-protonated-OH groups of silicon oxide) are fitted between a supply reservoir containing drug dissolved in an electrolyte solution and the external electrolyte (such as extracellular fluid). Pumping ensues via electro-osmotic flow when a direct current of the proper polarity is applied across the membrane (emanating between electrodes placed on either side of the membrane). The system is self-contained and useful for drugs which provide benefit when delivered in pulses (such as parathyroid hormone), at programmed intervals (such as fertility hormones, diabetes control agents, anti-obesity hormones), or delivered by external activation (pain medication, antidotes, stimulants, resuscitation agents).

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